2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W001080R
    3,4-Dihydroxybenzeneacetic acid (Standard)
    3,4-Dihydroxybenzeneacetic acid (Standard) is the analytical standard of 3,4-Dihydroxybenzeneacetic acid. This product is intended for research and analytical applications. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid (Standard)
  • HY-44358
    Remdesivir nucleoside monophosphate
    		99.98%
    Remdesivir nucleoside monophosphate is a metabolite of Remdesivir. Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV.
    Remdesivir nucleoside monophosphate
  • HY-W014993
    1,3-Dimethyluric acid
    		99.36%
    1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
    1,3-Dimethyluric acid
  • HY-118844
    Flumazenil acid
    		99.97%
    Flumazenil acid is a metabolite of Flumazenil. Flumazenil is a GABAA receptor antagonist.
    Flumazenil acid
  • HY-124087
    (±)-2-Propyl-4-pentenoic acid
    		≥98.0%
    (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity.
    (±)-2-Propyl-4-pentenoic acid
  • HY-Z0075
    (Z)2S,4R-Sacubitril
    (Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    (Z)2S,4R-Sacubitril
  • HY-B1348
    Dimethadione
    		99.93%
    Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal.
    Dimethadione
  • HY-B1986
    p,p'-DDE
    		99.91%
    p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.
    p,p'-DDE
  • HY-131637
    Desacetyl bisacodyl
    		≥99.0%
    Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion.
    Desacetyl bisacodyl
  • HY-131466
    N-Methyl Palbociclib
    		99.94%
    N-Methyl Palbociclib is an impurity of Palbociclib (HY-50767). Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor.
    N-Methyl Palbociclib
  • HY-B1984
    p,p'-DDD
    		99.71%
    p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.
    p,p'-DDD
  • HY-135392
    N-Desmethyl Pimavanserin
    		98.88%
    N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
    N-Desmethyl Pimavanserin
  • HY-118614
    β-Nicotyrine
    		99.35%
    β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid.
    β-Nicotyrine
  • HY-17616
    Ingenol disoxate
    		99.92%
    Ingenol disoxate (LEO 43204) is a drug metabolite, that exhibits potential in ameliorating actinic keratosis.
    Ingenol disoxate
  • HY-135847
    Desmethyl ferroquine
    		98.02%
    Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains.
    Desmethyl ferroquine
  • HY-133813A
    Apovincaminic acid hydrochloride salt
    		≥98.0%
    Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.
    Apovincaminic acid hydrochloride salt
  • HY-100052
    6-Hydroxybentazon
    		99.91%
    6-Hydroxybentazon is a phase I metabolite of bentazone, and bentazone is a chemical for use in herbicides.
    6-Hydroxybentazon
  • HY-138166
    Rosuvastatin lactone
    		98.56%
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone
  • HY-136596
    Apalutamide-COOH
    		99.76%
    Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
    Apalutamide-COOH
  • HY-14572
    PR-104A
    		98.11%
    PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
    PR-104A
Cat. No. Product Name / Synonyms Application Reactivity